Water Quality
Valuing Regional Water Supply Planning and Conservation Alternatives
Water for Life: Addressing a 21st Century Crisis
Susan M. Morris, Ph.D.
Research Geneticist
National Center for Toxicological Research
Evaluation of Genetic Toxicity in a Non-Traditional Animal Model
An important aspect in the evaluation of genetic toxicity is the extrapolation of data from animal models to human risk assessment. However, human subject studies are limited by the difficulties in controlling for nutritional, environmental, and health factors. In order to circumvent these limitations, our laboratory has developed and validated genetic safety assays in a non-human primate (NHP) animal model. Methods for and results obtained with the lymphocyte-HPRT and RBC-PIG-A assays, FISH-chromosome painting to detect chromosome aberrations, and flow cytometric determination of the micronucleus frequency will be presented.
