Water quality

Valuing Regional Water Supply Planning and Conservation Alternatives

Water for Life: Addressing a 21st Century Crisis

Matias Attene-Ramos
Visiting Fellow
NIH Chemical Genomics Center

Human Qantitative High Throughout Screening of Drinking Water DBPs

As part of the U.S. Tox21 initiative, the NIH Chemical Genomics Center (NCGC) is developing and optimizing cell-based and biochemical assays suitable for quantitative high throughput screening (qHTS) in a 1536-well format. This effort aims to generate pathway profiles for environmental compounds that will facilitate the evaluation of mechanisms of toxicity and prioritization for more extensive testing, as well as the development of predictive models for in vivo toxicity. The specific use of this approach for the characterization of water DBPs toxicity will be discussed.